I have yet to try it, but the Foundry VTT module for Forbidden Lands sounds good— and with digital hexcrawling, you have a pretty replayable map with no stickers to tear off (or vinyl ones to buy to reset the map).

While I was reading this, it reminded me of Monte Cook’s The Darkest House, which isn’t really a full game in and of itself, but is more a multiverse connective tissue, though still, it seems to be one of the few things designed specifically for online play.