I think part of it comes down to paradigm of what it means and how you read it.

Like, if we’re excusing humanity by saying Cthulhu did it, then I agree. And sometimes we do that. (We being Geeks.)

If, otoh, it’s metaphor and not literal, then it’s different. Not always cleanly so, but potentially so.

That is to say if vampires murder inner city homeless, so people are innocent because monsters, that’s crappy. If vampires are just a metaphor for humans killing other humans, and we are actually still saying “this is us, doing it to each other” then that’s a different thing.

For example, “Cthulhu was behind the Holocaust, humans could never be that evil” will drive me to rage. OTOH, “In the Black Mill’s” take of “this is a way of putting a literal face on subtle systemic ways that industrialization actually murdered a generation of workers” is a very different thing.

So really, when you play US, or WoD, are you playing people or are you playing things that excuse people? Is a Vamp a litteral inhuman monster, or is it a literary monster, which is to say a human making manifest something that is already monstrous about us?