That makes sense, but my experience is such that I would never trust my read of a space well enough, but that might be because of some of the specific spaces I’ve been invited to run games.
Now, if I had the opportunity to flip it, ie, if I knew these people well beforehand but knew they weren’t generally RPGers or I was able to very clearly say “this is a game that’s going to deal with certain traditional notions of gender very centrally, and I won’t proceed unless everyone is sure they are comfortable with that; there will be opportunities to subvert those notions,” then I would go ahead with confidence.