There are several things you can do to lower the footprint. First, there is a fantastic webapp called Gloomy Companion. It replaces all the cards and attack modifiers on the table. Also, it already knows all the monsters and bosses for every scenario. So no time needed to pull out the cards. johreh.github.io – Gloomy Companion

Yes, the more you play, the quicker it gets, as you learn your characters skills, and how they work with your team.